Prolonged vs intermittent infusion of piperacillin/tazobactam in critically ill patients

- In critically ill patients, physiologic changes occur

- Piperacillin/ tazobactam is antibiotic where time above MIC feature is important for bacterial killing

- We described the rational of continous infusion of piperacillin/ tazobactam

- We also perfromed a systematic review comparing continous with other mode of infusion of this antibiotic specifically in critically care patients

- We showed that piperacillin/ tazobactam showed somehow benefit above other mode of infusion, but the level of evidence is only moderate

- The abstract of the paper can be found here.